Simulink models are commonly employed to simulate and test complex systems such as Cyber-Physical Systems (CPSs). These systems are becoming highly configurable, and techniques from the product line engineering context (e.g., feature models) are being acquired by industrial practitioners to model the variability. Having variability in these systems means that there might be several configurations to test. Selecting relevant configurations by considering feature models following combinatorial techniques has been widely investigated by the software engineering community. However, efficiently testing each configuration has attracted little attention, which is not that trivial. One important aspect when testing such systems is automation. This tool paper presents ASTERYSCO, which aims at automatically generating test system instances in Simulink for testing specific configurations of configurable CPSs.